Diatrizoate meglumine
Cystografin, Diatrizoate Diatrizoate, Gastrografin, Hypaque, Md, Md-gastroview, Sinografin, Urovist (diatrizoate meglumine) is a small molecule pharmaceutical. Diatrizoate meglumine was first approved as Cystografin on 1982-01-01.
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Cystografin (discontinued: Angiovist, Cardiografin, Cystografin, Hypaque, Urovist cysto, Urovist meglumine diu/ct)
CombinationsDiatrizoate meglumine diatrizoate, Gastrografin, Md-gastroview (discontinued: Angiovist, Diatrizoate, Gastrovist, Hypaque, Md, Md-76r, Renocal, Sinografin)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Diatrizoate meglumine
+
Diatrizoate sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| GASTROGRAFIN | Bracco Diagnostics | N-011245 RX | 1982-01-01 | 1 products, RLD, RS |
Show 7 discontinued
Diatrizoate meglumine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CYSTOGRAFIN | Bracco Diagnostics | N-010040 RX | 1982-01-01 | 1 products, RLD |
| CYSTOGRAFIN DILUTE | Bracco Diagnostics | N-010040 RX | 1982-11-09 | 1 products, RLD |
Show 7 discontinued
Diatrizoate meglumine
+
Iodipamide meglumine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SINOGRAFIN | Bracco Diagnostics | N-011324 DISCN | 1982-01-01 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cystografin | New Drug Application | 2018-04-15 |
| cystografin dilute | New Drug Application | 2018-10-02 |
| diatrizoate meglumine and diatrizoate sodium | ANDA | 2024-04-23 |
| gastrografin | New Drug Application | 2021-10-04 |
| hypaque | 2006-04-13 | |
| hypaque - cysto | 2007-08-03 | |
| hypaque sodium | 2007-08-03 | |
| md gastroview | ANDA | 2021-01-01 |
| md-gastroview | ANDA | 2014-09-29 |
Indications
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Clinical
Clinical Trials
43 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intestinal obstruction | D007415 | — | K56.60 | — | 1 | 2 | 3 | 5 | 10 |
| Gallstones | D042882 | EFO_0004210 | — | — | — | — | 1 | 1 | 2 |
| Cholelithiasis | D002769 | EFO_0004799 | K80 | — | — | — | 1 | 1 | 2 |
| Cholecystolithiasis | D041761 | EFO_1000864 | — | — | — | — | 1 | 1 | 2 |
| Ileus | D045823 | — | — | — | 1 | 1 | 1 | — | 2 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | — | — | 1 | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | — | — | 1 | — | 1 |
| Healthy volunteers/patients | — | — | — | — | — | — | 1 | — | 1 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | — | — | 1 | — | 1 |
| Gastroschisis | D020139 | EFO_1000949 | Q79.3 | — | — | — | 1 | — | 1 |
Show 4 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | 2 | — | — | 2 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | 1 | 2 | 1 | — | — | 2 |
| Dilated cardiomyopathy | D002311 | HP_0001644 | I42.0 | 1 | 2 | 1 | — | — | 2 |
| Colonic neoplasms | D003110 | — | C18 | — | — | 1 | — | 1 | 2 |
| Insulin resistance | D007333 | HP_0000855 | — | — | 1 | 1 | — | — | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | 1 | — | — | 1 |
| Infertility | D007246 | HP_0000789 | — | — | — | 1 | — | — | 1 |
| Flushing | D005483 | — | R23.2 | — | — | 1 | — | — | 1 |
| Pathologic constriction | D003251 | — | — | — | — | 1 | — | — | 1 |
| Urethral stricture | D014525 | HP_0012227 | — | — | — | 1 | — | — | 1 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Constipation | D003248 | HP_0002019 | K59.0 | — | 1 | — | — | — | 1 |
| Fecal impaction | D005244 | — | K56.41 | — | 1 | — | — | — | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | 1 | — | — | — | 1 |
| Fibrosis | D005355 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Behcet syndrome | D001528 | EFO_0003780 | M35.2 | 1 | — | — | — | — | 1 |
| Retinitis | D012173 | — | H30.9 | 1 | — | — | — | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | 1 | — | — | — | — | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 1 | — | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | — | — | — | — | 1 |
| Adenocarcinoma of lung | D000077192 | — | — | 1 | — | — | — | — | 1 |
| Cellular immunity | D007111 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Esophageal achalasia | D004931 | HP_0002571 | K22.0 | — | — | — | — | 2 | 2 |
| Colorectal neoplasms | D015179 | — | — | — | — | — | — | 2 | 2 |
| Underactive urinary bladder | D000077295 | — | — | — | — | — | — | 2 | 2 |
| Hypokinesia | D018476 | — | — | — | — | — | — | 2 | 2 |
| Urinary bladder neck obstruction | D001748 | EFO_1000840 | N32.0 | — | — | — | — | 2 | 2 |
| Cystocele | D052858 | — | — | — | — | — | — | 2 | 2 |
| Esophageal motility disorders | D015154 | — | K22.4 | — | — | — | — | 1 | 1 |
| Muscle spasticity | D009128 | HP_0001257 | — | — | — | — | — | 1 | 1 |
| Diffuse esophageal spasm | D015155 | EFO_1001785 | K22.4 | — | — | — | — | 1 | 1 |
| Esophageal diseases | D004935 | EFO_0009544 | K22.9 | — | — | — | — | 1 | 1 |
Show 15 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Diatrizoate meglumine |
| INN | sodium amidotrizoate |
| Description | Amidotrizoic acid is a member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography. It has a role as a radioopaque medium, an environmental contaminant and a xenobiotic. It is an organoiodine compound, a member of benzoic acids and a member of acetamides. It is a conjugate acid of an amidotrizoic acid anion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(=O)O)c1I.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO |
Identifiers
| PDB | — |
| CAS-ID | 131-49-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200839 |
| ChEBI ID | 31812 |
| PubChem CID | 2140 |
| DrugBank | DB00271 |
| UNII ID | V5403H8VG7 (ChemIDplus, GSRS) |
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Safety
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347 adverse events reported
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